深圳醫學科學院Shawn Xu Lab現面向社會公開招聘副研究員/助理研究員、博士后、科研助理。

Shawn Xu Lab at the Shenzhen Medical Academy of Sciences(SMART) is now recruiting Associate Investigators/Assistant Investigators,Postdoctoral Fellows and Research Assistants.

課題組簡介丨Group Introduction

生物感知包括兩大類：一類是對外部環境的感受，即外感受；另一類是對身體內部狀態的整體感受，即內感受。外感受涵蓋對外界溫度、光線、聲音、氣味、壓力等信號的感知，是我們連接世界、適應環境并做出行為決策的關鍵生理基礎，幫助我們回答一個最基本的問題：“我身處何處？環境如何？”內感受則不僅包括內臟痛等感覺，還涉及呼吸頻率、體溫、口渴、饑餓、疲勞等身體狀態，是我們感知自我、產生情緒和維持生命的重要生理過程，幫助我們回答另一個基本問題：“我自身感覺怎么樣？”此外，生物感知還對代謝、衰老等關鍵生命過程發揮決定性調控作用。生物感知功能異常，既是耳鳴、耳聾、色盲、視力損傷等經典感覺障礙的直接病因，也作為核心癥狀廣泛出現在神經退行性疾病、慢性疼痛、糖尿病、心血管疾病等多種重大疾病中。因此，從分子—細胞—環路多層次闡明生物感知的過程與分子機制，對于發現新型疾病治療靶點、解析疾病機理具有重要意義。

Shawn Xu lab focuses on sensory biology, aiming to understand how we sense both the external environment (exteroception) and internal world (interoception) using C. elegans and mouse models. Exteroception allows us to sense external cues such as temperature, light, sound, odorants, tastants, and touch, serving as a key physiological foundation for connecting us to the external world, adapting to our surroundings, and guiding behavioral decisions. Interoception, on the other hand, not only underlies visceral pain and related sensations but also regulates physiological states such as respiratory rate, core body temperature, thirst, hunger, and fatigue. It is a vital physiological process that controls self-perception, emotional experience, and the maintenance of life. Furthermore, exteroception and interoception play key roles in regulating other vital physiological processes such as metabolism and aging. Dysfunction in exteroception/interoception is not only a direct cause of classical sensory disorders such as tinnitus, deafness, color blindness, and visual impairment, but also represents a core symptom widely associated with various human diseases, including neurodegenerative diseases, chronic pain, diabetes, and cardiovascular diseases. As such, elucidating the molecular, cellular and circuit mechanisms of exteroception and interoception is of great significance for developing novel therapeutics.

Shawn Xu Lab聚焦于生物感知的前沿研究，課題組負責人許獻忠（Shawn Xu）教授是感知生物學領域的知名學者，帶領課題組以線蟲(C. elegans)和小鼠為研究模型，深入探索了動物感知溫度、壓力、光、聲音、氣味、味道等感覺信號的分子細胞機制，首次證實秀麗隱桿線蟲除觸覺、味覺和嗅覺外，還具備視覺、聽覺、本體覺，即其具備全部六種主要感覺模態，充分確立了線蟲作為研究感知生物學理想遺傳模型的地位；在此基礎上，課題組通過經典遺傳學手段在線蟲中篩選和鑒定出多個新型感知受體，比如新型光感受器LITE-1、新型冷感受體GLR-3/GluK2、新型堿性感受體TMC-1/mTMC3、機械敏感性離子通道TRP-4/TRPN1，并解析了其信號傳導機制；在小鼠模型中證實了多個受體分子及信號通路的功能保守性。此外，他們還深入揭示了多條關鍵神經環路處理感覺信號以調節動物運動行為和藥物依賴性的具體作用及機制。課題組的研究還表明，除了影響大腦功能和行為之外，溫度和氣味等感覺信號也能夠調節衰老和壽命等其他生理過程，并闡明了其背后的遺傳與神經機制。這些研究拓展并加深了我們對感覺信號調控大腦功能、行為以及衰老過程的理解。

Professor Shawn Xu is a leading scientist in sensory biology. Using C. elegans and mice as models, Shawn Xu lab has made a series of contributions to our understanding of how animals detect and process sensory signals such as temperature, light, sound, touch, smell, and taste. The group was the first to demonstrate that, in addition to touch, taste, and smell, the nematode C. elegans also possesses the senses of light, airborne sound, and proprioception. These discoveries established that C. elegans has all six primary sensory modalities, fully establishing this animal as a powerful genetic model for the study of sensory biology. Building on these foundational discoveries, the Xu lab has identified multiple novel sensory receptors, including the photoreceptor LITE-1, the cold receptor GLR-3/GluK2, the alkaline receptor TMC-1/mTMC3, and the mechanosensitive channel TRP-4/TRPN1, among others. Importantly, they have demonstrated the functional conservation of some of these sensory receptors and their downstream signaling pathways using mouse models. Furthermore, they have characterized how neural circuits process sensory signals to regulate behavior and drug dependence. Moreover, their work has revealed that beyond brain function and behavior, sensory signals such as temperature and smell also regulate other vital physiological processes such as aging and longevity, and has elucidated the underlying genetic and neural mechanisms. These studies have expanded and deepened our understanding of how sensory cues regulate brain function, behavior, and aging.

許獻忠（Shawn Xu）博士曾任美國密歇根大學講席教授，2026年全職加入深圳醫學科學院，擔任生物構造與互作研究所資深研究員。他長期深耕生物感知領域，以通訊作者在Cell、Nature、Neuron、Nature Neuroscience、Cell Metabolism、Nature Aging、Developmental Cell等國際頂級期刊上發表多篇原創研究成果，這些開創性工作填補了該領域的多項研究空白，奠定了線蟲感知生物學的研究基礎。未來，課題組將繼續依托線蟲(C. elegans)和小鼠模型，重點推進以下三方面工作：一是篩選新型外感受與內感受感知受體，解析其信號傳導機制與結構功能關系；二是從分子、細胞和環路水平解碼感覺信號調控腦功能、行為、代謝、衰老等生理過程的作用機制；三是靶向感知受體開發與篩選小分子創新藥物，助力前沿科學發現向突破性療法的有效轉化。

Dr. Xu previously held Bernard W. Agranoff Collegiate Professorship at the University of Michigan. In 2026, Dr. Xu joined the Institute of Bio-Architecture and Bio-Interactions of SMART as a senior investigator. Dr. Xu has published many research articles in high profile journals such as Cell, Nature, Neuron, Nature Neuroscience, Cell Metabolism, Nature Aging, and Developmental Cell. Moving forward, Professor Xu’s group will continue to leverage C. elegans and mouse models to: i) identify novel sensory receptors detecting various exteroceptive and interoceptive signals and characterize their physiological functions and structure-function relationships; ii) elucidate how sensory signals regulate brain function, behavior, metabolism, and aging at the molecular, cellular, and circuit levels; and iii) screen for small molecules targeting sensory receptors to translate fundamental knowledge into novel therapeutics.

崗位要求及福利待遇

Positions and Benefits

副研究員/助理研究員（2名）Associate Investigator

Assistant Investigator (2 positions)

工作內容

Job Responsibilities

1.在課題組長指導下獨立開展科研工作；

Conduct independent research under the guidance of the PI.

2.獨立或協助申請國內外的科研項目和論文撰寫；

Independently or jointly apply for research grants and write research papers.

3.協助指導實驗室博后、學生和科研助理的研究工作；

Assist in supervising postdocs, students, and research assistants.

4.協助實驗室管理工作。

Support laboratory management.

應聘條件

Requirements

1.具有國內外一流研究機構博士學位和博士后研究經歷；

Possess a Ph.D. degree and postdoctoral research experience from leading research institutions in China or abroad.

2.以第一作者或通訊作者發表過多篇高水平科研論文；

Have published multiple high-impact scientific papers as the first author or corresponding author.

3.具有神經生物學、生理學、遺傳學、生物化學或細胞生物學等專業背景，基礎知識扎實；

Have a solid academic background in neurobiology, physiology, genetics, biochemistry, or cell biology.

4.具有良好溝通能力和團隊協作能力、優良學術道德、嚴謹科學態度、強烈探索興趣，勤奮，追求卓越，具有獨立開展科研工作的能力；

Possess excellent communication and teamwork skills, high academic integrity, a rigorous scientific attitude, a strong passion for discovery, diligence, a commitment to excellence, and the ability to conduct independent research.

5.能熟練以英語作為工作語言進行口頭和書面學術交流。

Be proficient in using English as a working language for both oral and written academic communication.

博士后（5-6名）

Postdoctoral Fellow (5-6 positions)

工作內容

Job Responsibilities

1.在課題組長指導下開展獨立或合作科研工作；

Conduct independent or collaborative research under the guidance of the PI.

2.協助申請各類科研項目。

Assist in applying for research grants.

應聘條件

Requirements

1.已獲得博士學位，以第一作者在本專業領域發表或即將發表研究論文至少一篇，具有獨立開展科研工作的能力；

Have obtained a Ph.D. degree, with at least one research paper published or about to be published as the first author in a relevant field, and possess the ability to conduct independent research.

2.具有神經生物學、生理學、遺傳學、生物化學或細胞生物學等專業背景，基礎知識扎實；

Have a solid academic background in neurobiology, physiology, genetics, biochemistry, or cell biology.

3.具有強烈進取心和責任感，良好的團隊協作意識，勤奮，追求卓越，具有獨立開展科研工作的能力；

Be highly motivated and responsible, with strong teamwork spirit, diligence, a commitment to excellence, and the ability to conduct independent research.

4.具有良好的英文科技文獻閱讀和寫作能力。

Have a good command of English for reading and writing scientific literature.

科研助理-I（線蟲C. elegans方向 2名）

Research Assistant I – with C. elegans experience (2 positions)

工作內容

Job Responsibilities

1.協助實驗室建設及管理；

Assist in laboratory management.

2.協助副研究員/助理研究員、博士后、博士生的科研工作；

Assist Associate/Assistant Investigators, Postdoctoral Fellows, and PhD students in research work.

3.可在課題組長指導下相對獨立地開展科研工作；

Conduct relatively independent research under the supervision of the PI.

4.協助完成實驗室安排的其他工作。

Assist with other tasks assigned by the laboratory.

應聘條件

Requirements

1.有線蟲C. elegans科研經歷；

Applicants should have research experience in C. elegans.

2.碩士學歷優先，本科學歷需具備相關工作經驗；

Master's degree preferred; bachelor's degree requires relevant work experience.

3.有責任心，操作能力強，有良好的協作和溝通能力；

Be responsible, skilled in laboratory operations, and possess strong collaboration and communication abilities.

4.有較好的英文閱讀和寫作能力。

Have good English reading and writing proficiency.

科研助理-II（小鼠及其他方向 2名）

Research Assistant II – with experience using mouse and other models (2 positions)

工作內容

Job Responsibilities

1.協助實驗室建設及管理；

Assist in laboratory management.

2.協助副研究員/助理研究員、博士后、博士生的科研工作；

Assist Associate/Assistant Investigators, Postdoctoral Fellows, and PhD students in research work.

3.可在課題組長指導下相對獨立地開展科研工作；

Conduct relatively independent research under the supervision of the PI.

4.協助完成實驗室安排的其他工作。

Assist with other tasks assigned by the laboratory.

應聘條件

Requirements

1.有小鼠操作經驗或細胞和分子生物學實驗技能的申請者優先；

Applicants with experience in mouse handling or cell and molecular biology techniques are preferred.

2.碩士學歷優先，本科學歷需具備相關工作經驗；

Master's degree preferred; bachelor's degree requires relevant work experience.

3.有責任心，操作能力強，有良好的協作和溝通能力；

Be responsible, skilled in laboratory operations, and possess strong collaboration and communication abilities.

4.有較好的英文閱讀和寫作能力。

Have good English reading and writing proficiency.

福利待遇

Benefits

1.按照本單位薪酬體系，提供具有市場競爭力的薪酬福利待遇，具體薪酬根據應聘者資歷和成果面議；

Provide a competitive salary and benefits package based on the institute’s compensation system, with specific pay determined according to the candidate’s qualifications and achievements;

2.享受國家規定的相關福利，享受帶薪年休假、員工體檢等；

Enjoy statutory benefits, paid annual leave, regular health check-ups, and other employee welfare programs;

3.提供良好科研訓練和科研環境；

Provide excellent research training and a supportive research environment;

4.若符合相關規定，可協助申請相關人才補助及相關配套待遇；

For qualified candidates, assistance will be provided in applying for relevant talent subsidies and supporting programs;

5.對于科研助理，工作表現優秀者，根據本人意愿，課題組可推薦申請研究生項目；

For Research Assistants and Visiting Students with outstanding performance, the group may recommend them for graduate study programs upon request.

應聘材料及方式

Application Materials and Process

應聘者請提供以下材料

Applicants should provide

1.完整的個人中文或英文簡歷，包括教育背景、科研經歷及成果、主要科研技能、所獲獎項、個人科研興趣等；

A complete CV in Chinese or English, including educational background, research experience and achievements, key scientific skills, awards, and personal research interests;

2.請列出至少2位推薦人信息；

Please list the names of at least 2 referees.

3.其它能夠說明科研和工作能力的材料。

Other materials that can demonstrate the applicant’s research and professional capabilities.

應聘者請將PDF版應聘材料作為附件按照以下任一方式投遞至郵箱（應聘材料主題請注明“應聘崗位－姓名－專業”），待審核后會盡快安排時間面試。

Please send the application materials inPDFformat to Email.(Email subject: “Position – Name – Major”). Qualified candidates will be notified for an interview.

應聘材料予以保密，待遇面議。

All applications will be kept confidential, and compensation is negotiable.

本招聘信息在職位未滿前長期有效。

This recruitment notice remains open until all positions are filled.

申請材料

請將簡歷按照以下任一方式投遞至郵箱。

投遞簡歷請選擇：深圳醫學科學院Shawn Xu Lab

簡歷投遞方式（可選任一）：

1. 掃描二維碼投遞簡歷；

3. 點擊鏈接投遞簡歷：https://data.bioart.com.cn/f/p0EB2y（復制鏈接至瀏覽器投遞簡歷）

課題組招聘廣告請發送至：bioarthr@bioart.com.cn

制版人：半夏